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There are several matches for 'ACT domain-containing protein'.
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7148 matches
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organism
protein
1)
Caenorhabditis elegans
K01C8.1 -
ACT
domain
-
containing
protein
.
[a.k.a. WBGene00010456, 4.3.1.19, CE36943,
ACT domain-containing protein
]
2)
Caenorhabditis elegans
Y51H7C.9 -
ACT
domain
-
containing
protein
.
[a.k.a. CELE_Y51H7C.9, WBGene00021787, 4.3.1.19,
ACT domain-containing protein
]
3)
Homo sapiens
UBXN10 - UBX
domain
-
containing
protein
10; VCP/p97-binding
protein
required for ciliogenesis.
Acts
as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT- B) in cilia. UBX
domain
-
containing
proteins
act
as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97 ; Belongs to the UBXN10 family.
[a.k.a. CCDS205, NX_Q96LJ8, ENSG00000162543]
4)
Homo sapiens
BAHD1 - Bromo adjacent homology
domain
-
containing
1
protein
; Heterochromatin
protein
that
acts
as a transcription repressor and has the ability to promote the formation of large heterochromatic
domains
. May
act
by recruiting heterochromatin
proteins
such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin
proteins
. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3.
[a.k.a. NM_014952.4, XP_011519670.2, KIAA0945]
5)
Homo sapiens
GAPVD1 - GTPase-activating
protein
and VPS9
domain
-
containing
protein
1;
Acts
both as a GTPase-activating
protein
(GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking.
Acts
as a GEF for the Ras-related
protein
RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...]
[a.k.a. ENSP00000419767, Q9Y4N0, HGNC:23375]
6)
Homo sapiens
TDRD3 - Tudor
domain
-
containing
protein
3; Scaffolding
protein
that specifically recognizes and binds dimethylarginine-
containing
proteins
. In nucleus,
acts
as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits
proteins
at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-
containing
proteins
.
[a.k.a. 5GVD, AL354764, OMIM:614392]
7)
Homo sapiens
MAGI3 - Membrane-associated guanylate kinase, WW and PDZ
domain
-
containing
protein
3;
Acts
as a scaffolding
protein
at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated
proteins
suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the [...]
[a.k.a. CCDS860.1, Q5TCQ9, OTTHUMG00000011737]
8)
Homo sapiens
CARD14 - Caspase recruitment
domain
-
containing
protein
14;
Acts
as a scaffolding
protein
that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.
[a.k.a. XP_024306703, ENSG00000141527, UPI000013D81B]
9)
Homo sapiens
WDR83 - WD repeat
domain
-
containing
protein
83; Molecular scaffold
protein
for various multimeric
protein
complexes.
Acts
as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by
acting
as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May
act
by recruiting signaling complexes to a specific upstream activato [...]
[a.k.a. BAG36848.1, ENSP00000448331, NP_001093207]
10)
Homo sapiens
WDFY2 - WD repeat and FYVE
domain
-
containing
protein
2;
Acts
in an adapter
protein
-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti- adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By si [...]
[a.k.a. ENST00000267142, ENST00000460145, 115825]
11)
Homo sapiens
ELMOD1 - ELMO
domain
-
containing
protein
1;
Acts
as a GTPase-activating
protein
(GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family.
[a.k.a. NP_061182.3, NM_001130037, ENSG00000110675]
12)
Homo sapiens
ELMOD2 - ELMO
domain
-
containing
protein
2;
Acts
as a GTPase-activating
protein
(GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.
[a.k.a. XP_005262943, XM_005262885.3, ENSP00000476419]
13)
Homo sapiens
ELMOD3 - ELMO
domain
-
containing
protein
3;
Acts
as a GTPase-activating
protein
(GAP) for ARL2 with low specific activity.
[a.k.a. NX_Q96FG2, DFNB88, ENST00000423095.7]
14)
Homo sapiens
LIMD2 - LIM
domain
-
containing
protein
2;
Acts
as an activator of the
protein
-kinase ILK, thereby regulating cell motility.
[a.k.a. uc002jbj.5, AK092301, ENST00000578067.5]
15)
Homo sapiens
BEND6 - BEN
domain
-
containing
protein
6;
Acts
as a corepressor of recombining binding
protein
suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis.
[a.k.a. XP_016865896.1, C6orf65, BEND6_HUMAN]
16)
Homo sapiens
ANKIB1 - Ankyrin repeat and IBR
domain
-
containing
protein
1; Might
act
as an E3 ubiquitin-
protein
ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates; Belongs to the RBR family.
[a.k.a. KIAA1386, URS00008B645B, AK001179]
17)
Homo sapiens
KHDRBS1 - KH
domain
-
containing
, RNA-binding, signal transduction-associated
protein
1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter
protein
in signal transduction cascades by binding to SH2 and SH3
domain
-
containing
proteins
. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also
acts
as a putative regulator of mRNA stability and/or translation rates and mediates [...]
[a.k.a. uc001bub.5, R-HSA-162582, Q99760]
18)
Homo sapiens
ANKRD13C - Ankyrin repeat
domain
-
containing
protein
13C;
Acts
as a molecular chaperone for G
protein
-coupled receptors, regulating their biogenesis and exit from the ER.
[a.k.a. NP_110443.3, XP_016857904, OMIM:615125]
19)
Homo sapiens
SERTAD2 - SERTA
domain
-
containing
protein
2;
Acts
at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-
containing
transcription factors. May
act
as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.
[a.k.a. Sei-2, D50917, TRIP-Br2]
20)
Homo sapiens
TXNDC11 - Thioredoxin
domain
-
containing
protein
11; May
act
as a redox regulator involved in DUOX
proteins
folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.
[a.k.a. ENST00000575349, NP_001310953.1, URS0000EBDE54]
7148 matches
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